Computer modeling and simulation have a wide range of applications in mechanical power, control, computer science, industrial manufacturing, physics, etc. and ICMSOA is aiming to promote a wide and in-depth academic exchange in modeling, simulation, optimization and algorithms in related fields. Since 2019, the 1st ICMSOA2019 was held at Sanya, the 2nd conference ICMSOA2020 was held online via Tencent Meeting due to the epidemic situation, the 3rd ICMSOA2021 was held at Sanya and all previous conference proceedings were published by IOP Publishing and indexed by Ei Compendex/Scopus, ect. In this year, 2022 the 4th International Conference on Modeling, Simulation, Optimization and Algorithm (ICMSOA 2022) will be held during Nov. 11-13, 2022 at Sanya, Hainan Province, China.